Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Evaluation of silver nanoparticles (AgNPs) and anti-GD2-AgNP antibody-drug conjugates as novel neuroblastoma therapies

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Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): MacLeod, Haley Ann, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Kaplan, David R, Degree committee member (dgc): Kerr, Leslie R, Degree granting institution (dgg): Trent University
Abstract: <p>Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell… more
Full Text: Evaluation of silver nanoparticles (AgNPs) and anti-GD2AgNP antibody-drug conjugates as novel neuroblastoma therapies A thesis submitted to the Committee of Graduate Studies in Partial Fulfillment of the requirements for the Degree of Master of Science in …

Corticosterone Promotes Development of Cannibalistic Morphology and Inhibits Tissue Regeneration in Axolotls (Ambystoma mexicanum)

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Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): MacFarlane, Shawn Patric Harris, Thesis advisor (ths): Kerr, Leslie R, Thesis advisor (ths): Murray, Dennis L, Degree committee member (dgc): Kapron, Carolyn M, Degree granting institution (dgg): Trent University
Abstract: <p>Salamanders are capable of tissue regeneration throughout all life-stages, which requires the dedifferentiation of mature cells to regrow lost tissues. Dedifferentiation is promoted by degradation of the extracellular matrix by matrix metalloproteases, as well as lysosomal degradation of intracellular and cell-surface proteins that mark cells as part of a mature lineage. Salamanders are… more
Full Text: CORTICOSTERONE PROMOTES DEVELOPMENT OF CANNIBALISTIC MORPHOLOGY AND INHIBITS TISSUE REGENERATION IN AXOLOTLS (AMBYSTOMA MEXICANUM) A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfilment of the Requirements for the Degree of Master …