Trent University Graduate Thesis Collection

Item Description

Identifier

tula:etd

Type

Collection

Language

eng

Extent

1 item

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Displaying 1 - 3 of 3

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Displaying 1 - 3 of 3

Corticosterone Promotes Development of Cannibalistic Morphology and Inhibits Tissue Regeneration in Axolotls (Ambystoma mexicanum)

Year: 2018, 2018

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): MacFarlane, Shawn Patric Harris, Thesis advisor (ths): Kerr, Leslie R, Thesis advisor (ths): Murray, Dennis L, Degree committee member (dgc): Kapron, Carolyn M, Degree granting institution (dgg): Trent University

Abstract: <p>Salamanders are capable of tissue regeneration throughout all life-stages, which requires the dedifferentiation of mature cells to regrow lost tissues. Dedifferentiation is promoted by degradation of the extracellular matrix by matrix metalloproteases, as well as lysosomal degradation of intracellular and cell-surface proteins that mark cells as part of a mature lineage. Salamanders are… more

Evaluation of silver nanoparticles (AgNPs) and anti-GD2-AgNP antibody-drug conjugates as novel neuroblastoma therapies

Year: 2018, 2018

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): MacLeod, Haley Ann, Thesis advisor (ths): Brunetti, Craig R, Degree committee member (dgc): Kaplan, David R, Degree committee member (dgc): Kerr, Leslie R, Degree granting institution (dgg): Trent University

Abstract: <p>Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell… more

Time-dependent effects of predation risk on stressor reactivity and growth in developing larval anurans (Lithobates pipiens)

Year: 2017, 2017

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Longhi, Jessica N., Thesis advisor (ths): Murray, Dennis L, Thesis advisor (ths): Kerr, Leslie R, Degree committee member (dgc): Emery, R.J. Neil, Degree granting institution (dgg): Trent University

Abstract: <p>The predator vs. prey dynamic is an omnipresent factor in ecological systems that may drive changes in life history patterns in prey animals through behavioural, morphological, and physiological changes. Predation risk can have profound effects on the life history events of an animal, and is influenced by the neuroendocrine stress response. Activation of the hypothalamic-pituitary-… more