Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Ustilago maydis (D.C.) Corda is a biotrophic pathogen that secretes effectors to establish and maintain a relationship with its host, Zea mays. In this pathosystem, the molecular function of effectors is well-studied, but the regulation of effector gene expression remains largely unknown. This study characterized Zfp1, a putative U. maydis Zn(II)2Cys6 transcription factor, as a modulator… more Full Text: CHARACTERIZATION OF A Zn(II)2Cys6 TRANSCRIPTION FACTOR IN Ustilago maydis AND ITS ROLE IN PATHOGENESIS A dissertation submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the …
Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Understanding the maintenance and spread of invasive diseases is critical in evaluating threats to biodiversity and how to best minimize their impact, which can by done by monitoring disease occurrences across time and space. I sought to apply existing and upcoming molecular tools to assess fluctuations in both presence and strain variation of frog virus 3 (FV3), a species of Ranavirus,… more Full Text: FROG VIRUS 3: TRACKING VIRAL SPREAD USING MOLECULAR TOOLS A thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Sciences TRENT UNIVERSITY …
Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Neuroblastoma (NB) has one of the highest mortality rates in pediatric oncology due to relapsed and refractory disease. Current aggressive multi-modal treatments are inhibited by dose-limiting toxicities and are associated with late-effects and secondary malignancies, emphasizing the necessity for novel therapeutics. Uniquely, most NB cells highly express disialoganglioside (GD2) a cell… more Full Text: Evaluation of silver nanoparticles (AgNPs) and anti-GD2AgNP antibody-drug conjugates as novel neuroblastoma therapies A thesis submitted to the Committee of Graduate Studies in Partial Fulfillment of the requirements for the Degree of Master of Science in …
Year: 2016, 2016
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The aim of this work was to identify the DNA sequences recognized by the Giardia TBP (gTBP) in vivo by using a chromatin immunoprecipitation assay (ChIP). Since a specific antibody for the protein of interest is required for this assay, a company was contracted to produce and purify a custom polyclonal antibody from the immunization of rabbits. Recombinant GST-gTBP was produced at a… more Full Text: CHARACTERISATION OF THE GIARDIA TATABINDING PROTEIN - PREPARATION FOR AN IN VIVO APPROACH A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfilment of the Requirements for the degree of Master of Science in the Faculty of Arts and …
Year: 2015, 2015
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Iridoviruses are large (120-200nm) double stranded DNA viruses that contain an icosahedral capsid. The iridoviridae family is composed of five genera that infect a wide range of poikilothermic vertebrates (Lymphocystivirus, Ranavirus and Megalocyivirus) and invertebrate hosts (Iridovirus, Chloriridovirus). Frog virus 3 (FV3) is a member of the Ranavirus genus, and is commonly used as a… more Full Text: Characterization of frog virus 3 75L and its binding partner LITAF A thesis submitted to the Committee on Graduate Studies In partial fulfillment of the requirements for the degree of Doctor of Philosophy TRENT UNIVERSITY Peterborough, ON, Canada …
Year: 2014, 2014
Member of: Trent University Graduate Thesis Collection
Abstract: <p><italic>Ustilago maydis</italic> (DC) Corda is the causal agent of 'common smut of corn'. Completion of the <italic>U. maydis</italic> lifecycle is dependent on development inside its host, <italic>Zea mays</italic>. Symptoms of <italic>U. maydis</italic> infection include chlorosis and the formation of tumours on all aerial corn… more Full Text: GENOME ANNOTATION, GENE CHARACTERIZATION, AND THE FUNCTIONAL ANALYSIS OF NATURAL ANTISENSE TRANSCRIPTS IN THE FUNGAL PLANT PATHOGEN Ustilago maydis A dissertation submitted to the Committee of Graduate Studies in partial fulfillment of the requirements …
