Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
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Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Immunotherapies Targeting the Amyotrophic Lateral Sclerosis-Associated Protein TDP-43

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Esposto, Josephine, Thesis advisor (ths): Martic, Sanela, Degree committee member (dgc): Rafferty, Steven, Degree committee member (dgc): Huber, Robert, Degree granting institution (dgg): Trent University
Abstract: <p>Transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) pathology, including fibrillar aggregates and mutations, develops in amyotrophic lateral sclerosis (ALS) and is characterized by hyperphosphorylation and aggregation patterns, a mechanism largely understudied. In addition, ALS remains without a cure. Herein, in vitro aggregation of phosphorylated TDP-43 was explored, and… more