Trent University Graduate Thesis Collection

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    Advancements and Challenges in Ciguatoxin Detection: Developing a High- Resolution Mass Spectrometric Method for the Identification of P-CTX-3B

    Year: 2024, 2024
    Member of: Trent University Graduate Thesis Collection
    Name(s): Creator (cre): Prytulka, Natasha Grace, Thesis advisor (ths): Hintelmann, Holger, Thesis advisor (ths): Stock, Naomi, Degree committee member (dgc): Metcalfe, Chris, Degree granting institution (dgg): Trent University
    Abstract: <p>The detection of ciguatoxins (CTXs) in biological samples is challenging due to their low concentrations, the presence of various congeners, and the absence of standardized methods. This study uses high resolution mass spectrometry (HRMS) with P-CTX-3B as a reference standard. The protonated molecules ([M+H]+) were most prevalent, especially when acetonitrile/water was utilized,… more