Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
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Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Using the Social Amoeba Dictyostelium discoideum as a Model to Study CLN5 Disease

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Year: 2026, 2026
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Kim, William David, Thesis advisor (ths): Huber, Robert J, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Shafer, Aaron, Degree committee member (dgc): Saville, Barry, Degree granting institution (dgg): Trent University
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), collectively referred to as Batten disease, are a group of neurodegenerative diseases that affect all ages, primarily children. Batten disease is caused by mutations in 1 of the 13 ceroid lipofuscinosis neuronal (CLN) genes (CLN1-CLN8, CLN10-CLN14), each of which causes an NCL subtype when mutated. One of the NCL subtypes, CLN5 disease, is… more