Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Impaired contextual fear discrimination learning after long-term amygdala kindling

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Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Francis, Travis James, Thesis advisor (ths): Fournier, Neil M, Degree committee member (dgc): Lehmann, Hugo, Degree committee member (dgc): Melvin, Neal, Degree granting institution (dgg): Trent University
Abstract: <p>Cognitive impairments, such as memory loss, are a frequent and devastating co-morbidity associated with epilepsy. The neurobiological mechanisms through which recurrent seizures induce cognitive impairments are not well understood. New neurons born after seizures develop abnormal morphological and functional characteristics that promote network hyperexcitability and hippocampal… more

Altered Hippocampal Regulation of Immediate Early Genes after Pentylenetetrazol-Induced Seizures

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Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Kalinina, Alena, Thesis advisor (ths): Fournier, Neil M, Degree committee member (dgc): Lehmann, Hugo, Degree granting institution (dgg): Trent University
Abstract: <p>Seizures induce long-term changes in gene expression in the hippocampus. Experimental evidence has demonstrated a significant effect of epileptic activity on the activity of neurons that participate in complex cognitive and behavioural processes. The present series of experiments involving kindling with subconvulsive doses of PTZ demonstrates a link between seizures and altered immediate… more