Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Stress can significantly affect neurobiological processes crucial for learning and memory. While repeated stress enhances fear memory, it impairs memory retrieval. In most studies, however, stress exposure typically preceded fear and extinction learning. Thus, the impact of previously acquired memories formed before exposure to stress is not well understood. The goal of this thesis is to… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): McCallum, Daniel, Thesis advisor (ths): Lehmann, Hugo, Degree committee member (dgc): Chan-Reynolds, Michael, Degree committee member (dgc): Humphreys, Terry, Degree committee member (dgc): Toufexis, Donna, Degree granting institution (dgg): Trent University Abstract: <p>Damage to the hippocampus (HPC) causes retrograde amnesia for some memories, but spaced learning mitigates this. Contextual fear conditioning (CFC) studies in rats demonstrate that distributing conditioning over multiple sessions makes a memory less vulnerable to HPC damage, and it has been suggested this occurs through incremental strengthening of the memory outside the HPC via separate… more
