Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Immunotherapies Targeting the Amyotrophic Lateral Sclerosis-Associated Protein TDP-43

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Esposto, Josephine, Thesis advisor (ths): Martic, Sanela, Degree committee member (dgc): Rafferty, Steven, Degree committee member (dgc): Huber, Robert, Degree granting institution (dgg): Trent University
Abstract: <p>Transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) pathology, including fibrillar aggregates and mutations, develops in amyotrophic lateral sclerosis (ALS) and is characterized by hyperphosphorylation and aggregation patterns, a mechanism largely understudied. In addition, ALS remains without a cure. Herein, in vitro aggregation of phosphorylated TDP-43 was explored, and… more

Electrochemical Biosensors for Neurodegenerative Disease Biomarkers: Investigations into the origin and diagnosis of Alzheimer's disease and amyotrophic lateral sclerosis

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Wallace, William, Thesis advisor (ths): Martic, Sanela, Degree committee member (dgc): Rafferty, Steven, Degree committee member (dgc): Vreugdenhil, Andrew, Degree granting institution (dgg): Trent University
Abstract: <p>The onset of neurodegenerative diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are typically characterised by the aggregation of protein biomarkers into cytotoxic fibrils. Novel means of analysing these biomarkers are needed to expand the literature toward earlier diagnosis of these conditions. Electrochemical sensors could offer the sensitivity and… more

Characterizing the demographic history and prion protein gene variation to infer susceptibility to chronic wasting disease in a naïve population of white-tailed deer (Odocoileus virginianus)

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Haworth, Sarah, Thesis advisor (ths): Shafer, Aaron B.A., Thesis advisor (ths): Northrup, Joseph M., Degree committee member (dgc): Martic, Sanela, Degree granting institution (dgg): Trent University
Abstract: <p>Assessments of the adaptive potential of natural populations are essential for understanding and predicting responses to environmental stressors like climate change and infectious disease. The range of stressors species face in a human-dominated landscape, often have contrasting effects. White-tailed deer (Odocoileus virginianus, deer) are expanding in the northern part of their range… more