Trent University Graduate Thesis Collection

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Identifier
tula:etd
Type
Collection
Language
eng
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1 item
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Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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The role of Cln5 in autophagy, using a Dictyostelium discoideum model of Batten disease

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Year: 2020, 2020
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): McLaren, Meagan, Thesis advisor (ths): Huber, Robert J., Degree committee member (dgc): Kapron, Carolyn, Degree committee member (dgc): Brunetti, Craig, Degree granting institution (dgg): Trent University
Abstract: <p>This thesis investigated the role of the neuronal ceroid lipofuscinosis protein, Cln5, during autophagy. This was accomplished by performing well-established assays in a Dictyostelium cln5 knockout model (cln5-). In this study, cln5- cells displayed a reduced maximum cell density during growth and impaired cell proliferation in autophagy-stimulating media. cln5- cells had an increased… more
Full Text: The role of Cln5 in autophagy, using a Dictyostelium discoideum model of Batten disease A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for Degree of Master of Science in the Faculty of Arts and Science …