Trent University Graduate Thesis Collection

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    Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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    Impaired contextual fear discrimination learning after long-term amygdala kindling

    Year: 2019, 2019
    Member of: Trent University Graduate Thesis Collection
    Name(s): Creator (cre): Francis, Travis James, Thesis advisor (ths): Fournier, Neil M, Degree committee member (dgc): Lehmann, Hugo, Degree committee member (dgc): Melvin, Neal, Degree granting institution (dgg): Trent University
    Abstract: <p>Cognitive impairments, such as memory loss, are a frequent and devastating co-morbidity associated with epilepsy. The neurobiological mechanisms through which recurrent seizures induce cognitive impairments are not well understood. New neurons born after seizures develop abnormal morphological and functional characteristics that promote network hyperexcitability and hippocampal… more