Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Prewer, Erin, Thesis advisor (ths): Kyle, Christopher J, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Shafer, Aaron, Degree committee member (dgc): Saville, Barry, Degree granting institution (dgg): Trent University Abstract: <p>Molecular and genomic tools provide a deeper understanding of the ecology and evolution of species and their capacity to adapt to changing selective pressures, where diversity is presumedly linked to higher fitness and evolutionary potential. Molecular tools can also illustrate how historical processes affect contemporary genetic variation to predict how current population trends may… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Mutations in the CLN7 (MFSD8) gene, causes CLN7 disease, a subtype of neuronal ceroid lipofuscinosis. MFSD8 is a lysosomal transmembrane protein that transports chloride across membranes. Experimentation regarding Dictyostelium discoideum revealed that mfsd8 deficiency altered lysosomal enzyme activity. During starvation, the aggregation of mfsd8¬¬- cells was delayed, and cells formed… more
