Year: 2023, 2023
Member of: Trent University Graduate Thesis Collection
Abstract: <p>To examine comorbid pain sensitivity, temporal lobe epilepsy was modeled with a 42-stimulation amygdala kindling paradigm using rats. Sham and kindled rats' mechanical allodynia was not different before the formalin conditioned place aversion (FCPA) test. FCPA behaviour was not different, but twenty-four hours later kindled rats showed mechanical allodynia. Thermal sensitivity 48… more Full Text: Affective Pain Hypersensitivity in the Amygdala Kindling Model of Temporal Lobe Epilepsy A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Epilepsy is associated with a variety of cognitive, emotional, and pain-related symptoms, such as impaired memory and learning, increased risk of anxiety and depression, and increased pain sensitivity. Unfortunately, these symptoms are generally untreated with typical pharmacological interventions, which tend to target seizure activity (i.e., ictogenesis) and not the subsequent… more Full Text: ENDOCANNABINOID TREATMENT FOR THE BEHAVIOURAL AND HISTOPATHOLOGICAL ALTERATIONS OF EPILEPSY A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and …
