Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Insights from Dictyostelium: Examining the role of cellular stress in Batten disease

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Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Thanabalasingam, Aruban, Thesis advisor (ths): Huber, Robert J, Degree committee member (dgc): Yee, Janet, Degree committee member (dgc): Donaldson, Micheal, Degree granting institution (dgg): Trent University
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of fatal neurodegenerative disorders that primarily affect children. Several subtypes of NCLs have been reported, each being caused by a mutation in a distinct ceroid lipofuscinosis neuronal (CLN) gene; this results in aberrant lysosome function and the accumulation of lipoprotein aggregates (known… more

Mfsd8 regulates growth and multicellular development in Dictyostelium discoideum

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Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Yap, Shyong Quan, Thesis advisor (ths): Huber, Robert J, Degree committee member (dgc): Kapron, Carolyn, Degree committee member (dgc): Morrison, Erin N, Degree granting institution (dgg): Trent University
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of inherited neurodegenerative lysosomal storage disorders. CLN7 disease is a subtype of NCL that is caused by mutations in the MFSD8 gene. MFSD8 encodes a lysosomal transmembrane protein that is predicted to play a role in transporting small substrates across membranes. However, little is known… more

Interactome study of the Giardia intestinalis nuclear localized cytochrome b5

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Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Batoff, Gordon William, Thesis advisor (ths): Yee, Janet, Degree committee member (dgc): Huber, Robert J, Degree committee member (dgc): Saville, Barry, Degree granting institution (dgg): Trent University
Abstract: <p>Giardia intestinalis is a waterborne enteric parasite that lacks mitochondria and the capacity for heme biosynthesis. Despite this, Giardia encodes several heme proteins, including four cytochrome b5 isotypes (gCYTB5-I – IV) of unknown function. The aim of this thesis is to gain insight into the function of the Giardia cytochrome b5 isotype III (gCYTB5-III) that is found in the nucleus,… more