Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Abstract: <p>ABSTRACT
Patients who undergo chemotherapy often complain of a persistent 'brain fog' that can be present up to years after treatment ends. This fog is expressed as marked impairments in areas of learning, memory and mental health. As it stands, researchers have yet to determine the mechanism at fault for these impairments. The present experiment investigates if the… more Full Text: The Effect of Systemic Temozolomide on Learning, Emotional Behaviour, and Hippocampal Synaptic Plasticity: Implications for chemotherapy-induced cognitive impairment A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Memories pertaining to fearful events are some of the most salient and long-lasting memories, as they are critical to the survival of an organism. Seizures induce aberrant changes within temporal lobe and limbic brain structures that are critical for supporting fear memories. Seizures can occur at any time; therefore, it is imperative that research address how seizures impact previously… more Full Text: Retrograde Amnesia of Fear Memories Following Pentylenetetrazol Kindling A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Science TRENT …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Memories which typically require the hippocampus (HPC) can become represented in structures outside of the HPC, and therefore resistant to HPC damage, but, the properties of these memories are poorly understood. Some research has suggested that the HPC continually contributes to memories that are resistant to hippocampal damage, and without this support, they are weaker and more… more Full Text: Evidence of an Interaction Between Memory Stores for Long-Term Context Fear Memory in the Rat A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and …
Year: 2020, 2020
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Temporal lobe epilepsy increases risk for developing major depression, and conversely, depression increases risk for development of epilepsy. The mechanisms responsible for the widely observed bi-directional relationship between epilepsy and depression are currently poorly understood. One reason why our understanding of shared etiology has had little improvement is due to the lack of… more Full Text: USE OF RAPID AMYGDALA KINDLING WITH CORTICOSTERONE SUPPLEMENTATION AS A MODEL OF EPILEPSY-DEPRESSION COMORBIDITY A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the …
Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Seizures induce long-term changes in gene expression in the hippocampus. Experimental evidence has demonstrated a significant effect of epileptic activity on the activity of neurons that participate in complex cognitive and behavioural processes. The present series of experiments involving kindling with subconvulsive doses of PTZ demonstrates a link between seizures and altered immediate… more Full Text: ALTERED HIPPOCAMPAL REGULATION OF IMMEDIATE EARLY GENES AFTER PENTYLENETETRAZOL-INDUCED SEIZURES A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts …
Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Cognitive impairments, such as memory loss, are a frequent and devastating co-morbidity associated with epilepsy. The neurobiological mechanisms through which recurrent seizures induce cognitive impairments are not well understood. New neurons born after seizures develop abnormal morphological and functional characteristics that promote network hyperexcitability and hippocampal… more Full Text: Impaired contextual fear discrimination learning after long-term amygdala kindling A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Science …
