Trent University Graduate Thesis Collection

Item Description

Identifier

tula:etd

Type

Collection

Language

eng

Extent

1 item

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Displaying 1 - 2 of 2

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Displaying 1 - 2 of 2

The Localization and Functional Characterization of a DNAJC5-like Protein in Dictyostelium discoideum

Singh_trentu_0513N_11316-Thumbnail Image.png

Year: 2025, 2025

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Singh, Jagjot, Thesis advisor (ths): Huber, Robert, Degree committee member (dgc): Bates, Holly, Degree committee member (dgc): Rafferty, Steven, Degree granting institution (dgg): Trent University

Abstract: <p>DNAJC5, an HSP40 member, supports synaptic vesicle release and protein folding byactivating HSP70 ATPase activity. In humans, it localizes to presynaptic terminals and
endomembrane compartments that are involved in protein trafficking. Mutations in DNAJC5
cause CLN4 disease, a rare adult-onset Batten disease. Dictyostelium discoideum, a model for
neurodegenerative research, encodes a… more

An in vitro characterization of the novel binding properties of the Giardia TATA-binding protein

Freitag_trentu_0513N_11279-Thumbnail Image.png

Year: 2025, 2025

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Freitag, Kieran, Thesis advisor (ths): Yee, Janet, Degree committee member (dgc): Brunetti, Craig, Degree committee member (dgc): Huber, Robert, Degree granting institution (dgg): Trent University

Abstract: <p>The TATA-binding protein (TBP) is a key regulator of eukaryotic transcription initiation. The TBP homolog from Giardia intestinalis (gTBP) is highly divergent among all TBPs; notably lacking three of the four phenylalanine residues to unwind double- stranded DNA. I show that gTBP preferentially binds to single-stranded DNA (ssDNA) in two modes based on sequence and protein concentration… more