Trent University Graduate Thesis Collection

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    Affective Pain Hypersensitivity in the Amygdala Kindling Model of Temporal Lobe Epilepsy

    Year: 2023, 2023
    Member of: Trent University Graduate Thesis Collection
    Name(s): Creator (cre): MacDonald, Kaylea, Thesis advisor (ths): Fournier, Neil M., Degree committee member (dgc): Martin, Loren J., Degree committee member (dgc): Brown, Liana E., Degree granting institution (dgg): Trent University
    Abstract: <p>To examine comorbid pain sensitivity, temporal lobe epilepsy was modeled with a 42-stimulation amygdala kindling paradigm using rats. Sham and kindled rats' mechanical allodynia was not different before the formalin conditioned place aversion (FCPA) test. FCPA behaviour was not different, but twenty-four hours later kindled rats showed mechanical allodynia. Thermal sensitivity 48… more