Trent University Graduate Thesis Collection

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Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
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Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Ligand Binding Properties of Giardia Flavohemoglobin

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Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Nezamololama, Novin, Thesis advisor (ths): Rafferty, Steven P, Degree committee member (dgc): Vreugdenhil, Andrew, Degree committee member (dgc): Bates, Holly, Degree granting institution (dgg): Trent University
Abstract: <p>The parasitic protist Giardia intestinalis possesses flavohemoglobin (gFlHb), an enzyme that detoxifies nitric oxide to the less harmful nitrate, and is a potential target for antigiardial drugs that act as ligands to the iron of its heme cofactor. In this work, the binding constants KD of gFlHb, three active-site variants (Q54L, L58A, Y30F) and the E. coli flavohemoglobin (Hmp) towards… more