Year: 2026, 2026
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Kim, William David, Thesis advisor (ths): Huber, Robert J, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Shafer, Aaron, Degree committee member (dgc): Saville, Barry, Degree granting institution (dgg): Trent University Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), collectively referred to as Batten disease, are a group of neurodegenerative diseases that affect all ages, primarily children. Batten disease is caused by mutations in 1 of the 13 ceroid lipofuscinosis neuronal (CLN) genes (CLN1-CLN8, CLN10-CLN14), each of which causes an NCL subtype when mutated. One of the NCL subtypes, CLN5 disease, is… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Prewer, Erin, Thesis advisor (ths): Kyle, Christopher J, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Shafer, Aaron, Degree committee member (dgc): Saville, Barry, Degree granting institution (dgg): Trent University Abstract: <p>Molecular and genomic tools provide a deeper understanding of the ecology and evolution of species and their capacity to adapt to changing selective pressures, where diversity is presumedly linked to higher fitness and evolutionary potential. Molecular tools can also illustrate how historical processes affect contemporary genetic variation to predict how current population trends may… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Baecklund, Tristan Mackenzie, Thesis advisor (ths): Kyle, Christopher J, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Shafer, Aaron, Degree committee member (dgc): Brown, Glen, Degree granting institution (dgg): Trent University Abstract: <p>Heterogeneous environments impose discordant selective pressures on natural populations, where disparate biotic/abiotic factors and variable population connectivity, yield mosaic patterns of genetic variation on the landscape. The ability to maintain or change genetic mosaics of populations becomes key to persistence, as species increasingly need to adapt to rapidly changing… more Year: 2023, 2023
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Fungal pathogens adapt to environmental changes faster than their hosts, due in part to their adaptive mechanisms exhibited in response to stress. Ustilago maydis was used to investigate potential natural antisense transcript (NAT) RNA-mediated mechanisms that enhance fungal adaptation to stress. Of the 349 NATs conserved amongst U. maydis and two related smut fungi, five NATs were… more Full Text: Exploring the Role of Natural Antisense Transcripts in the Stress Response of Ustilago maydis A thesis submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree of Master of Science in the faculty of Arts and …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Kennedy , Victoria, Thesis advisor (ths): Saville, Barry, Degree committee member (dgc): Emery, Neil, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Farrow, Scott, Degree granting institution (dgg): Trent University Abstract: <p>Heavy metal pollution threatens human and ecosystem health. E. gracilis was investigated for its potential use in bioremediation due to its tolerance for heavy metals and ability to sequester them from the environment. E. gracilis can remove metals by producing metal binding compounds enriched in sulfur and nitrogen. In this thesis, E. gracilis cultures that were pretreated with elevated… more Full Text: The influence of sulfur and nitrogen on cadmium tolerance in Euglena gracilis: an RNA-sequencing investigation A thesis submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree of Master of Science in the …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Vanderwolf, Karen J, Thesis advisor (ths): Davy, Christina, Thesis advisor (ths): Kyle, Christopher, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): McAlpine, Donald, Degree granting institution (dgg): Trent University Abstract: <p>White-nose syndrome (WNS) is a skin disease of bats caused by the fungus Pseudogymnoascus destructans (Pd) that damages flight membranes during hibernation and can lead to death. The disease causes mortality of multiple bat species in eastern North America and is spreading into western North America. Future impacts of WNS on naïve bat populations are unknown. Variation in host… more Full Text: THE MYCOBIOME AND SKIN CHEMISTRY OF BAT WINGS IN RELATION TO WHITE-NOSE SYNDROME A dissertation submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the faculty of Arts and …
Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The emergence of fungal hybrid pathogens threatens sustainable crop production worldwide. To investigate hybridization, the related smut fungi, Ustilago maydis and Sporisorium reilianum, were selected because they infect a common host (Zea mays), can hybridize, and tools are available for their analysis. Hybrid dikaryons exhibited filamentous growth on plates but reduced virulence and… more Full Text: Fungal pathogen emergence: an Ustilago maydis x Sporisorium reilianum model A thesis submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree of Master of Science in the faculty of Arts and Science TRENT …
Year: 2020, 2020
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Ophidiomycosis (snake fungal disease) is caused by the pathogen Ophidiomyces ophiodiicola. Infected snakes exhibit dermal lesions, occasional systemic infections, and, in some cases, mortality. We studied snakes at Rondeau Provincial Park, Ontario, Canada, to explore whether ophidiomycosis develops during brumation or year-round. Throughout their active season, we quantified the… more Full Text: Disease ecology of ophidiomycosis in free-ranging snakes A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Science TRENT UNIVERSITY …
