Year: 2026, 2026
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Kim, William David, Thesis advisor (ths): Huber, Robert J, Degree committee member (dgc): Donaldson, Michael, Degree committee member (dgc): Shafer, Aaron, Degree committee member (dgc): Saville, Barry, Degree granting institution (dgg): Trent University Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), collectively referred to as Batten disease, are a group of neurodegenerative diseases that affect all ages, primarily children. Batten disease is caused by mutations in 1 of the 13 ceroid lipofuscinosis neuronal (CLN) genes (CLN1-CLN8, CLN10-CLN14), each of which causes an NCL subtype when mutated. One of the NCL subtypes, CLN5 disease, is… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Mutations in the CLN7 (MFSD8) gene, causes CLN7 disease, a subtype of neuronal ceroid lipofuscinosis. MFSD8 is a lysosomal transmembrane protein that transports chloride across membranes. Experimentation regarding Dictyostelium discoideum revealed that mfsd8 deficiency altered lysosomal enzyme activity. During starvation, the aggregation of mfsd8¬¬- cells was delayed, and cells formed… more Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of fatal neurodegenerative disorders that primarily affect children. Several subtypes of NCLs have been reported, each being caused by a mutation in a distinct ceroid lipofuscinosis neuronal (CLN) gene; this results in aberrant lysosome function and the accumulation of lipoprotein aggregates (known… more Full Text: Insights from Dictyostelium: Examining the role of cellular stress in Batten disease A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for Degree of Master of Science in the Faculty of Arts and Science …
Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of fatal neurodegenerative disorders that primarily affect children. Several subtypes of NCLs have been reported, each being caused by a mutation in a distinct ceroid lipofuscinosis neuronal (CLN) gene; this results in aberrant lysosome function and the accumulation of lipoprotein aggregates (known… more Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Giardia intestinalis is a waterborne enteric parasite that lacks mitochondria and the capacity for heme biosynthesis. Despite this, Giardia encodes several heme proteins, including four cytochrome b5 isotypes (gCYTB5-I – IV) of unknown function. The aim of this thesis is to gain insight into the function of the Giardia cytochrome b5 isotype III (gCYTB5-III) that is found in the nucleus,… more Full Text: Interactome study of the Giardia intestinalis nuclear localized cytochrome b5 A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Science TRENT …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of inherited neurodegenerative lysosomal storage disorders. CLN7 disease is a subtype of NCL that is caused by mutations in the MFSD8 gene. MFSD8 encodes a lysosomal transmembrane protein that is predicted to play a role in transporting small substrates across membranes. However, little is known… more Full Text: Mfsd8 regulates growth and multicellular development in Dictyostelium discoideum A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for Degree of Master of Science in the Faculty of Arts and Science TRENT …
