Year: 2026, 2026
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Seneviratne, Dev, Thesis advisor (ths): Martic, Sanela, Thesis advisor (ths): Emery, Neil, Degree committee member (dgc): Oleschuk, Richard, Degree committee member (dgc): Moorthy, Arun, Degree committee member (dgc): Burr, Wesley, Degree granting institution (dgg): Trent University Abstract: <p>Amyloid fibrils are fibrous protein aggregates that arise from misfolding and self-assembly processes, collectively referred to as amyloidosis. These aggregates are strongly associated with incurable neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and Amyotrophic Lateral Sclerosis (ALS). Elevated levels of Reactive Oxygen Species (ROS) and… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>In an effort to improve upon existing analytical methods, electrochemical sensors offer portable, cost-effective alternatives to traditional lab-based techniques. Recent advances in supramolecular chemistry offer a unique alternative to achieve high selectivity while also benefitting from facile scaling for mass production. Thus, by incorporating host-guest chemistry with electrochemical… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Innovative strategies to manage copious waste streams by upcycling feedstocks to valorized products which are then used in environmental remediation applications is an attractive circular economy model. This thesis explores this approach using waste wood generated from the milling of Chlorocardium rodiei (greenheart), a tropical hardwood species abundant in Guyana. We evaluate the… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Mutations in the CLN7 (MFSD8) gene, causes CLN7 disease, a subtype of neuronal ceroid lipofuscinosis. MFSD8 is a lysosomal transmembrane protein that transports chloride across membranes. Experimentation regarding Dictyostelium discoideum revealed that mfsd8 deficiency altered lysosomal enzyme activity. During starvation, the aggregation of mfsd8¬¬- cells was delayed, and cells formed… more Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Flavohemoglobins are enzymes primarily implicated in nitrosative stress due to their high nitric oxide (NO) dioxygenase activity and transcriptional upregulation in response to NO. Giardia intestinalis assemblages A, B, and E possess flavohemoglobins (gFlHb) that may function beyond their NO dioxygenase activity, potentially contributing to oxidative stress regulation, as transcriptional… more Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Giardia intestinalis is a parasitic protozoan that possesses a flavohemoglobin (gFlHb), an enzyme that plays a role in the detoxification of reactive nitrogen species (RNS) and reactive oxygen species (ROS) via its nitric oxide dioxygenase (NOD) activity as well as its NADH-oxidase activity. This enzyme is a potential target for imidazole-based antigiardial drugs that act as ligands of… more Full Text: Rapid Assays to Test for Flavohemoglobin Inhibitors A thesis submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree of Master of Science in the Faculty of Arts and Science Trent University Peterborough, …
Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Giardia intestinalis is a parasitic protozoan that possesses a flavohemoglobin (gFlHb), an enzyme that plays a role in the detoxification of reactive nitrogen species (RNS) and reactive oxygen species (ROS) via its nitric oxide dioxygenase (NOD) activity as well as its NADH-oxidase activity. This enzyme is a potential target for imidazole-based antigiardial drugs that act as ligands of… more Year: 2023, 2023
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Phenolic compounds are used in industry, such as agriculture and biotechnology, and inevitably end up in our environment. These compounds may serve as a phenolic precursor to produce raw materials for a wide range of applications. Chemical oxidation has been the common synthetic pathway to oxidize phenols and related compounds. However, traditional chemical approaches suffer from use of… more Full Text: Electrochemical versus Chemical Oxidation of Bulky Phenols: 2,6-diphenylphenol and 2,2dihydroxybiphenol A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty …
Year: 2023, 2023
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss in function of motor neurons. Elevated levels of biologically important metal ions, such as copper (II) (Cu(II)), zinc (II) (Zn(II)) or iron (III) (Fe(III)), may contribute to the disease. Moreover, Cu(II) interactions with other proteins associated with ALS have been investigated;… more Full Text: ELECTROCHEMICAL AND SURFACE ANALYSIS OF METAL IONS AND TDP-43 PROTEIN INTERACTIONS A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Science …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Amino acids make up proteins, which are the building blocks of life. A balance of amino acids is needed to maintain a healthy state. Tyrosine (Tyr) is synthesized from the metabolism of phenylalanine, which is an essential amino acid, meaning it can only be obtained from the diet. It is related to many metabolic and neurodegenerative diseases. Tyr can undergo post-translational… more Full Text: USING FLUORESCENT CARBON DOTS FOR BIOSENSING APPLICATIONS OF AMINO ACIDS A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master Science in the Faculty of Arts and Science TRENT …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>During the COVID-19 pandemic, nucleic acid and antibody-based testing methods were heavily relied upon, but can be costly, time-consuming and exhibit high false -negative and -positive rates. Thus, alternative strategies are needed. Viral antigens such as the SARS-CoV-2 spike (S) glycoprotein are critical in the function of the virus and useful as diagnostic biomarkers for viral… more Full Text: SARS-CoV-2 PROTEIN-BASED DETECTION USING LOCALIZED SURFACE PLASMON RESONANCE A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and Science TRENT …
Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Assessments of the adaptive potential of natural populations are essential for understanding and predicting responses to environmental stressors like climate change and infectious disease. The range of stressors species face in a human-dominated landscape, often have contrasting effects. White-tailed deer (Odocoileus virginianus, deer) are expanding in the northern part of their range… more Full Text: Characterizing the demographic history and prion protein gene variation to infer susceptibility to chronic wasting disease in a naïve population of white-tailed deer (Odocoileus virginianus) A Thesis Submitted to the Committee on Graduate Studies in …
Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) pathology, including fibrillar aggregates and mutations, develops in amyotrophic lateral sclerosis (ALS) and is characterized by hyperphosphorylation and aggregation patterns, a mechanism largely understudied. In addition, ALS remains without a cure. Herein, in vitro aggregation of phosphorylated TDP-43 was explored, and… more Full Text: IMMUNOTHERAPIES TARGETING THE AMYOTROPHIC LATERAL SCLEROSIS-ASSOCIATED PROTEIN TDP-43 A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Master of Science in the Faculty of Arts and …
Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The onset of neurodegenerative diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are typically characterised by the aggregation of protein biomarkers into cytotoxic fibrils. Novel means of analysing these biomarkers are needed to expand the literature toward earlier diagnosis of these conditions. Electrochemical sensors could offer the sensitivity and… more Full Text: ELECTROCHEMICAL BIOSENSORS FOR NEURODEGENERATIVE DISEASE BIOMARKERS: INVESTIGATIONS INTO THE ORIGIN AND DIAGNOSIS OF ALZHEIMER’S DISEASE AND AMYOTROPHIC LATERAL SCLEROSIS A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of …
