Trent University Graduate Thesis Collection

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tula:etd
Type
Collection
Language
eng
Extent
1 item
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Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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The Effect of SP600125 JNK Inhibitor on Cadmium-Treated Mouse Embryo Forelimb Bud Cells In Vitro

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Year: 2015, 2015
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Alhoesh, Afnan M., Thesis advisor (ths): Kapron, Carolyn, Degree committee member (dgc): Brenner, Ingrid, Degree committee member (dgc): Brunetti, Craig, Degree granting institution (dgg): Trent University
Abstract: <p>This study investigated the role of the JNK signaling pathway in cadmium-treated mouse embryo forelimb bud cells in vitro. Primary cultures of forelimb bud cells harvested at day 11 of gestation were pre-treated with JNK inhibitor SP600125, and incubated with or without CdCl2 for 15, 30, 60, 120 minutes and 24, 48 hours or 5 days. Endpoints of toxicity were measured through cell… more