Trent University Graduate Thesis Collection

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tula:etd
Type
Collection
Language
eng
Extent
1 item
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Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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The Localization and Functional Characterization of a DNAJC5-like Protein in Dictyostelium discoideum

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Year: 2025, 2025
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Singh, Jagjot, Thesis advisor (ths): Huber, Robert, Degree committee member (dgc): Bates, Holly, Degree committee member (dgc): Rafferty, Steven, Degree granting institution (dgg): Trent University
Abstract: <p>DNAJC5, an HSP40 member, supports synaptic vesicle release and protein folding byactivating HSP70 ATPase activity. In humans, it localizes to presynaptic terminals and
endomembrane compartments that are involved in protein trafficking. Mutations in DNAJC5
cause CLN4 disease, a rare adult-onset Batten disease. Dictyostelium discoideum, a model for
neurodegenerative research, encodes a… more