Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Affective Pain Hypersensitivity in the Amygdala Kindling Model of Temporal Lobe Epilepsy

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Year: 2023, 2023
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): MacDonald, Kaylea, Thesis advisor (ths): Fournier, Neil M., Degree committee member (dgc): Martin, Loren J., Degree committee member (dgc): Brown, Liana E., Degree granting institution (dgg): Trent University
Abstract: <p>To examine comorbid pain sensitivity, temporal lobe epilepsy was modeled with a 42-stimulation amygdala kindling paradigm using rats. Sham and kindled rats' mechanical allodynia was not different before the formalin conditioned place aversion (FCPA) test. FCPA behaviour was not different, but twenty-four hours later kindled rats showed mechanical allodynia. Thermal sensitivity 48… more

Endocannabinoid Treatment for the Behavioural and Histopathological Alterations of Epilepsy

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Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Godin, Simon, Thesis advisor (ths): Fournier, Neil M., Degree granting institution (dgg): Trent University
Abstract: <p>Epilepsy is associated with a variety of cognitive, emotional, and pain-related symptoms, such as impaired memory and learning, increased risk of anxiety and depression, and increased pain sensitivity. Unfortunately, these symptoms are generally untreated with typical pharmacological interventions, which tend to target seizure activity (i.e., ictogenesis) and not the subsequent… more