Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Knight, Caitlyn, Thesis advisor (ths): Kapron, Carolyn, Degree committee member (dgc): Tobin, Stephanie, Degree committee member (dgc): Huber, Robert, Degree committee member (dgc): West, Sarah, Degree granting institution (dgg): Trent University Abstract: <p>Cadmium is a toxic metal that has detrimental effects on blood vessel development and function. To examine the effect of varying concentrations of cadmium on angiogenesis, two in vitro assays were used. First, developing yolk sac blood vessels were studied in gestation day 8 mouse embryos exposed to medium alone, 1.25, or 1.75 μM cadmium chloride (CdCl2). Embryos exposed to 1.25 μM… more Full Text: Concentration-Dependent Effects of Cadmium on Mouse Angiogenesis In Vitro A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Science in the Faculty of Arts and Science TRENT UNIVERSITY …
Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Abstract: <p>I investigated the climate vulnerability of a cold-water salmonid by observing the upper thermal tolerance of brook trout (Salvelinus fontinalis) across multiple life stages. Using hatchery- and wild-ancestry fish, I assessed variation in thermal tolerances and carryover effects within and among brook trout life stages and populations that were reared under varying winter thermal regimes… more Full Text: Impacts of embryo incubation temperature on ontogenic thermal tolerance of brook trout (Salvelinus fontinalis) A Thesis submitted to the Committee on Graduate Studies In Partial Fulfillment of the Requirements for the Degree of Master of Science in the …
Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of inherited neurodegenerative lysosomal storage disorders. CLN7 disease is a subtype of NCL that is caused by mutations in the MFSD8 gene. MFSD8 encodes a lysosomal transmembrane protein that is predicted to play a role in transporting small substrates across membranes. However, little is known… more Full Text: Mfsd8 regulates growth and multicellular development in Dictyostelium discoideum A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for Degree of Master of Science in the Faculty of Arts and Science TRENT …
Year: 2020, 2020
Member of: Trent University Graduate Thesis Collection
Abstract: <p>This thesis investigated the role of the neuronal ceroid lipofuscinosis protein, Cln5, during autophagy. This was accomplished by performing well-established assays in a Dictyostelium cln5 knockout model (cln5-). In this study, cln5- cells displayed a reduced maximum cell density during growth and impaired cell proliferation in autophagy-stimulating media. cln5- cells had an increased… more Full Text: The role of Cln5 in autophagy, using a Dictyostelium discoideum model of Batten disease A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for Degree of Master of Science in the Faculty of Arts and Science …
Year: 2015, 2015
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Aquatic consumers frequently face nutritional limitation, caused in part, by imbalances between the nutrients supplied by primary producers and the metabolic demands of the consumers. These nutritional imbalances alter many ecological processes including consumer life-history traits, population dynamics, and food web properties. Given the important ecological role of organismal nutrition… more Full Text: NUTRIENT METABOLISM OF AN AQUATIC INVERTEBRATE AND ITS IMPORTANCE TO ECOLOGY A Thesis Submitted to the Committee on Graduate Studies in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in the Faculty of Arts and Science Trent …
Year: 2015, 2015
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Iridoviruses are large (120-200nm) double stranded DNA viruses that contain an icosahedral capsid. The iridoviridae family is composed of five genera that infect a wide range of poikilothermic vertebrates (Lymphocystivirus, Ranavirus and Megalocyivirus) and invertebrate hosts (Iridovirus, Chloriridovirus). Frog virus 3 (FV3) is a member of the Ranavirus genus, and is commonly used as a… more Full Text: Characterization of frog virus 3 75L and its binding partner LITAF A thesis submitted to the Committee on Graduate Studies In partial fulfillment of the requirements for the degree of Doctor of Philosophy TRENT UNIVERSITY Peterborough, ON, Canada …
Year: 2015, 2015
Member of: Trent University Graduate Thesis Collection
Abstract: <p>This study investigated the role of the JNK signaling pathway in cadmium-treated mouse embryo forelimb bud cells in vitro. Primary cultures of forelimb bud cells harvested at day 11 of gestation were pre-treated with JNK inhibitor SP600125, and incubated with or without CdCl2 for 15, 30, 60, 120 minutes and 24, 48 hours or 5 days. Endpoints of toxicity were measured through cell… more Full Text: The Effect of SP600125 JNK Inhibitor on Cadmium-Treated Mouse Embryo Forelimb Bud Cells In Vitro A thesis submitted to the Committee on Graduate Studies in partial fulfillment of the requirement for the Degree of Master of Science in the Faculty of Arts …
