Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Expression of Giardia intestinalis flavoenzyme GiOR-1 and characterization of its electron transfer properties

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Villeneuve, Tiffany C., Thesis advisor (ths): Rafferty, Steven, Degree committee member (dgc): Huber, Robert, Degree committee member (dgc): Brunetti, Craig, Degree granting institution (dgg): Trent University
Abstract: <p>Giardia intestinalis possesses four isotypes of cytochrome b5 (gCYTB-I-IV) that differ from their mammalian counterparts, suggesting different functions in this protozoan parasite. Although the recently discovered Giardia flavoenzyme, GiOR-1, reduces these cytochromes, its properties have not been thoroughly studied, owing to the difficulty in its expression. Here I describe successful… more

Immunotherapies Targeting the Amyotrophic Lateral Sclerosis-Associated Protein TDP-43

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Esposto, Josephine, Thesis advisor (ths): Martic, Sanela, Degree committee member (dgc): Rafferty, Steven, Degree committee member (dgc): Huber, Robert, Degree granting institution (dgg): Trent University
Abstract: <p>Transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) pathology, including fibrillar aggregates and mutations, develops in amyotrophic lateral sclerosis (ALS) and is characterized by hyperphosphorylation and aggregation patterns, a mechanism largely understudied. In addition, ALS remains without a cure. Herein, in vitro aggregation of phosphorylated TDP-43 was explored, and… more

Electrochemical Biosensors for Neurodegenerative Disease Biomarkers: Investigations into the origin and diagnosis of Alzheimer's disease and amyotrophic lateral sclerosis

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Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Wallace, William, Thesis advisor (ths): Martic, Sanela, Degree committee member (dgc): Rafferty, Steven, Degree committee member (dgc): Vreugdenhil, Andrew, Degree granting institution (dgg): Trent University
Abstract: <p>The onset of neurodegenerative diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are typically characterised by the aggregation of protein biomarkers into cytotoxic fibrils. Novel means of analysing these biomarkers are needed to expand the literature toward earlier diagnosis of these conditions. Electrochemical sensors could offer the sensitivity and… more