Trent University Graduate Thesis Collection

Item Description

Identifier

tula:etd

Type

Collection

Language

eng

Extent

1 item

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Displaying 1 - 2 of 2

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Displaying 1 - 2 of 2

The Localization and Functional Characterization of a DNAJC5-like Protein in Dictyostelium discoideum

Singh_trentu_0513N_11316-Thumbnail Image.png

Year: 2025, 2025

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Singh, Jagjot, Thesis advisor (ths): Huber, Robert, Degree committee member (dgc): Bates, Holly, Degree committee member (dgc): Rafferty, Steven, Degree granting institution (dgg): Trent University

Abstract: <p>DNAJC5, an HSP40 member, supports synaptic vesicle release and protein folding byactivating HSP70 ATPase activity. In humans, it localizes to presynaptic terminals and
endomembrane compartments that are involved in protein trafficking. Mutations in DNAJC5
cause CLN4 disease, a rare adult-onset Batten disease. Dictyostelium discoideum, a model for
neurodegenerative research, encodes a… more

Investigation of the Oxidative Activity of Giardia Flavohemoglobins

Decorso_trentu_0513N_11293-Thumbnail Image.png

Year: 2025, 2025

Member of: Trent University Graduate Thesis Collection

Name(s): Creator (cre): Decorso, Isabelle, Thesis advisor (ths): Rafferty, Steven, Degree committee member (dgc): Brunetti, Craig, Degree committee member (dgc): Martic, Sanela, Degree granting institution (dgg): Trent University

Abstract: <p>Flavohemoglobins are enzymes primarily implicated in nitrosative stress due to their high nitric oxide (NO) dioxygenase activity and transcriptional upregulation in response to NO. Giardia intestinalis assemblages A, B, and E possess flavohemoglobins (gFlHb) that may function beyond their NO dioxygenase activity, potentially contributing to oxidative stress regulation, as transcriptional… more