Trent University Graduate Thesis Collection

Item Description
Identifier
tula:etd
Type
Collection
Language
eng
Extent
1 item
Rights
Copyright for all items in the Trent University Graduate Thesis Collection is held by the author, with all rights reserved, unless otherwise noted.
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Insights from Dictyostelium: Examining the role of cellular stress in Batten disease

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Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Thanabalasingam, Aruban, Thesis advisor (ths): Huber, Robert J, Degree committee member (dgc): Yee, Janet, Degree committee member (dgc): Donaldson, Micheal, Degree granting institution (dgg): Trent University
Abstract: <p>The neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten disease, are a family of fatal neurodegenerative disorders that primarily affect children. Several subtypes of NCLs have been reported, each being caused by a mutation in a distinct ceroid lipofuscinosis neuronal (CLN) gene; this results in aberrant lysosome function and the accumulation of lipoprotein aggregates (known… more
Full Text: Insights from Dictyostelium: Examining the role of cellular stress in Batten disease A Thesis Submitted to the Committee of Graduate Studies in Partial Fulfillment of the Requirements for Degree of Master of Science in the Faculty of Arts and Science …

The effect of cytokinins on the metabolite secretome of Giardia intestinalis during trophozoite growth, nutrient deprivation, and encystation

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Year: 2024, 2024
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Vedanti, Ghatwala Vijaykumar, Thesis advisor (ths): Emery, Neil RJ, Thesis advisor (ths): Yee, Janet, Degree committee member (dgc): Kisiala, Anna B, Degree granting institution (dgg): Trent University
Abstract: <p>Giardia intestinalis is the causative agent of a diarrheal disease in mammals, but the mechanisms of disease pathogenesis are unclear. While proteins secreted by Giardia affect the host cells, the potential of hormone secretion has not been investigated to date. Cytokinins (CKs) are classified as phytohormones, but little is known about their role beyond plants. Mass spectrometry-based… more
Full Text: The effect of cytokinins on the metabolite secretome of Giardia intestinalis during trophozoite growth, nutrient deprivation, and encystation A thesis submitted to the Committee of Graduate Studies in partial fulfillment of the requirements for the degree …