Year: 2022, 2022
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Amino acids make up proteins, which are the building blocks of life. A balance of amino acids is needed to maintain a healthy state. Tyrosine (Tyr) is synthesized from the metabolism of phenylalanine, which is an essential amino acid, meaning it can only be obtained from the diet. It is related to many metabolic and neurodegenerative diseases. Tyr can undergo post-translational… more Year: 2021, 2021
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The onset of neurodegenerative diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) are typically characterised by the aggregation of protein biomarkers into cytotoxic fibrils. Novel means of analysing these biomarkers are needed to expand the literature toward earlier diagnosis of these conditions. Electrochemical sensors could offer the sensitivity and… more Year: 2020, 2020
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Poo Palam, Kosheela, Thesis advisor (ths): NARINE, SURESH S, Degree committee member (dgc): Vreugdenhil, Andrew, Degree committee member (dgc): Hill, Stephen, Degree committee member (dgc): Metcalfe, Chris, Degree granting institution (dgg): Trent University Abstract: <p>Energy storage efficiency and sustainability require advanced technologies and novel materials. Recently, bio-based phase change materials (PCMs) have received significant attention for thermal energy storage (TES) uses. Vegetable oils are versatile renewable feedstocks that are well suited for the development of sustainable, functional PCMs. PCMs derived from vegetable oil, which… more Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The parasitic protist Giardia intestinalis possesses flavohemoglobin (gFlHb), an enzyme that detoxifies nitric oxide to the less harmful nitrate, and is a potential target for antigiardial drugs that act as ligands to the iron of its heme cofactor. In this work, the binding constants KD of gFlHb, three active-site variants (Q54L, L58A, Y30F) and the E. coli flavohemoglobin (Hmp) towards… more Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>The parasitic protist Giardia intestinalis does not synthesize heme and lacks many common eukaryotic heme proteins, yet it expresses four cytochrome b5 (gCYTB5) isotypes of unknown function. These have low reduction potentials and distinct subcellular locations that are consistent with structural features and biological functions that differ from their mammalian counterparts. Isotype III… more Year: 2019, 2019
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Microfibres, which are threadlike particles < 5 mm, are the most common type of microplastic reported in the environment. However, few studies have focused on their abundance in background natural environments. This study assessed the abundance of microfibres in rainfall samples (from four precipitation monitoring stations) and across three headwater lake catchments that were in… more Year: 2018, 2018
Member of: Trent University Graduate Thesis Collection
Abstract: <p>Chemical presumptive tests are used as the primary detection method for latent bloodstain evidence. This work focuses on developing a forensic blood substitute which mimics whole blood reactivity to a luminol solution commonly used in presumptive testing. Designing safe and accessible materials that mimic relevant properties of blood is a recognized research need in forensic science.… more Year: 2016, 2016
Member of: Trent University Graduate Thesis Collection
Name(s): Creator (cre): Shetranjiwalla, Shegufta, Thesis advisor (ths): NARINE, SURESH S, Thesis advisor (ths): Vreugdenhil, Andrew, Degree committee member (dgc): Metcalfe, Chris, Degree committee member (dgc): Dawson, Peter, Degree granting institution (dgg): Trent University Abstract: <p>Thermoplastic poly(ester urethane)s (TPEU)s derived from vegetable oils possess inferior physical properties compared to their entirely petroleum-based counterparts due to the structural limitations and lower reactivity of the precursor lipid-derived monomers. The present work shows that high molecular weight of TPEUs with enhanced performance can be obtained from lipid-derived monomers… more
