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Universities produce a significant and increasing share of basic research that is later commercialized by firms. We argue that the university's prominence as a producer of basic research is the result of a differential efficiency in research production that cannot be replicated by firms or individual agents - teaching. By using research accomplishments to signal knowledge and attract tuition-paying students, universities are uniquely positioned to undertake certain types of research projects. However, in a market for innovation without patent rights, a significant and increasing number of basic research projects, that are social welfare improving, cannot be initiated by firms or universities. The extension of patent rights to university-generated research elegantly redresses this issue and leaves us to ponder important questions about the future of our innovation-driven economies.

Author Keywords: Innovation, Intellectual Property Rights, Research, Science Technology and Innovation Policy

Euglena gracilis is an enigmatic and adaptable organism that has great bioremediationpotential and is best known for its metabolic flexibility. The research done in this dissertation addresses (1) how growth conditions impact cellular composition, and (2) how chemometric approaches (such as statistical design of experiments and artificial neural networks) are viable alternatives to the conventional biosorption models for process optimization. Using high-resolution mass spectrometry for biosorbent characterization is a powerful way to assess the chemical characteristics of lyophilized and fractionated cells with high precision, especially to screen for compound classes that may have potentiality for rare earth element removal. Growth conditions impacted cellular composition and separated size fractions of cells yielded different molecular/chemical properties as described by compositional abundances, thus different biosorptive potential. Untargeted analysis demonstrated that exponential dark-grown cells with glucose supplementation were abundant in polyphenolic- and carbohydrate-like compounds, molecular species highly involved in rare earth element binding. Light grown cells had more heterogeneity and the highest molecular weighted fractions from light grown cells (fraction D) had the most abundances of polyphenolic- and protein-like structures. Chemometric modeling used identified the best and worst conditions for iii dysprosium sorption and showed that pH had the most significant influence on bioremoval. Bioremoval ranged from 37% at pH 8 to 91% at pH 3 at Dy concentration ranging from 1 to 100 μg L-1. The work presented in the PhD dissertation will aid in understanding the chemical characteristics of biosorbents by using a Van krevelen analysis of elemental ratios whether algal cells are grown in different environmental growth conditions, or when algal cell are size fractionated. This is especially applied for the screening for metal binding potentiality to Dysprosium. Chemometric methods provide an alternative method for the investigating factors for bioremoval, and applications for process optimization and for real-world applications. This dissertation will aid in understanding chemical characteristics when a biosorbent is grown in a given condition and which factors are important for rare earth element (REE) bioremoval. The significance of this work aims to look for alternate ways to screen biosorbents and using a more efficient experimental design for REE bioremoval.

Author Keywords: bioremoval, biosorption, chemometrics, dysprosium, euglena, mass spectrometry

Fishers (Pekania pennanti) were extirpated from many parts of Ontario in the early 20th century, but as of the early 2000s the species had recolonized most of its historical range. While the primary population genetic structure of fishers in central and eastern Ontario has not changed drastically over the past ten years, we did find evidence of increased secondary structure and a reduction in northward movement from southeastern Ontario, a site of recent immigration from the Adirondacks in northern New York. This may be indicative of a reduction in density and thus in density-dependent migration, or it may be a consequence of the population reaching equilibrium following a period of rapid expansion associated with recolonization. We also observed no variation within central and eastern Ontario at 14 of 15 candidate functional loci we screened, suggesting possible directional or stabilizing selection and a lack of adaptive potential.

Author Keywords: fisher, functional genes, Ontario, Pekania pennanti, population genetics, recolonization

Early diagnosis of autism spectrum disorder (ASD), while providing many benefits, presents challenges to clinicians such as predicting the stability of symptoms. Accurately predicting symptom severity allows clinicians to confidently diagnose and assign the most appropriate treatment. Little research exists to date to predict symptom severity in children with ASD who have not been exposed to treatment. The present file review examined prelinguistic skills as predictors of symptom severity in a group of young children (age: 18 – 64 months) with ASD (n = 199) who had not been exposed to significant levels of treatment. Hierarchical regression analyses demonstrated that of the two core diagnostic features (social communicative deficits and restricted repetitive behaviours), social communicative skills best predicted symptom severity. Furthermore, social communicative gestures predicted symptom severity after age, adaptive behaviour, restricted repetitive behaviours, and functional gestures had been accounted for.

Author Keywords: autism, gestures, predictors, prelinguistic, social communicative, symptom severity

The appearance of a two-dimensional electron gas (2DEG) in oxide interfaces between strontium titanate (STO) and other materials has become a major area of study. The behaviour of the 2DEG in STO is not well understood in part because the dielectric properties of STO are not well characterized. The differential susceptibility has a major impact on the electric fields within strontium titanate, and therefore to understand the 2DEG a better understanding of the susceptibility is needed. An expression for the soft mode phonon frequency of bulk strontium titanate is derived and used to model the susceptibility as a function of spatially homogeneous electric field, temperature and wavevector. This model is used to discuss the effect of spatially inhomogeneous electric fields and the local vs. nonlocal nature of the susceptibility. The critical exponents and the free energy are determined and discussed.

Author Keywords: critical exponents, differential susceptibility, quantum paraelectric, strontium titanate

Cytokinin biosynthesis in organisms aside from plant species has often been viewed as a byproduct of tRNA degradation. Recent evidence suggests that these tRNA degradation products may actually have a role in the development of these organisms, particularly fungi. This thesis examines the importance of cytokinins, a group of phytohormones involved in plant cell division and differentiation as well as the phytohormone abscisic acid, involved in plant response to environmental factors, and their presence and role in fungi.

An initial survey was conducted on 20 temperate forest fungi of differing nutritional modes. Using HPLC-ESI MS/MS, cytokinin and abscisic acid were detected in all fungi regardless of their mode of nutrition or phylogeny. The detection of the same seven CKs across all fungi suggested the existence of a common CK biosynthetic pathway and dominance of the tRNA pathway in fungi. Further, the corn smut fungus Ustilago maydis is capable of producing CKs separate from its host and different U. maydis strains induce disease symptoms of differing severity. To determine if CK production during infection alters disease development a disease time course was conducted on cob tissue infected with U. maydis dikaryotic and solopathogenic strains. Dramatic changes in phytohormones including an increase in ABA followed by increases in cisZCKs were detected in tumour tissue particularity in the more virulent dikaryon infection, suggesting a role for CKs in strain virulence. Mining of the U. maydis genome identified a sole tRNA-isopentenyltransferase, a key enzyme in CK biosynthesis. Targeted gene deletion mutants were created in U. maydis which halted U. maydis CK production and decreased pathogenesis and virulence in seedling and cob infections. CK and ABA profiling carried out during disease development found that key changes in these hormones were not found in deletion mutant infections and cob tumour development was severely impaired. These findings suggested that U. maydis CK production is necessary for tumour development in this pathosystem. The research presented in this thesis highlights the importance of fungal CKs, outlines the dominant CK pathway in fungi, identifies a key enzyme in U. maydis CK biosynthesis and reveals the necessity of CK production by U. maydis in the development of cob tumours.

Author Keywords: abscisic acid, cytokinins, high performance liquid chromatography-electrospray ionization tandem mass spectrometry, tRNA degradation pathway, Ustilago maydis, Zea mays

This thesis project explores landowner experiences of wind energy development through an inductive qualitative case study in Huron County, Ontario. The research included in-depth interviews with landowners focused on landscape and community change, participant observation of Environmental Review Tribunals (ERT), the gathering of participant photos, as well as relevant government and industry documents and media reports. The iterative data gathering and analysis were supported by my observations and reflections while living in affected communities and talking to participants. The study demonstrates how the health debate over wind can inform divisions between neighbours, that local politics have been given a token role as a place for resistance to wind energy development that fails to meaningfully influence projects, and that appeals are legalistic and do not provide an outlet, or place for appellants to be heard. Furthermore, the felt experience of tight knit and fragile communities were disrupted through land leases, as well as changes to the landscape. These disruptions impacted connections to, and associations with place, and are shown to have had negative emotional and physical impacts on some individuals. Supporters of wind development tied their mostly positive views of landscape change to a sense of disruption generally throughout the community. Insights from the research lead to a set of suggested actions that might improve the current situation at the levels of provincial policy, planning, local governance and industry practice.

Keywords: wind energy policy, planning, landscape, Ontario, rural communities

Author Keywords: Affect, landscape, Ontario, planning, Rural communities, Wind energy policy

The North American conservation movement and modern conservation model was created in part because of the exploitative commercial hunting industry that caused the collapse of species such as the bison and auk in the late 19th and early 20th centuries. These historical actions continue to shape views today and the public perception of hunting can often be negative. This thesis engaged with this question of social acceptability by conducting action research to determine hunters' motivations and how these might affect the way hunting is perceived. As part of this action research, I conducted nine in-depth interviews, a survey of 177 hunters, and a focus group to determine what the dominant motivations were for the hunters studied. I then suggest how the motivations discovered through the focus group, interviews, and survey can work towards the current and future social, economic, cultural, and environmental sustainability of hunting in Ontario.

Author Keywords: Ethics, Hunting, Motivations, Ontario, Social Acceptance, Sustainability

In this dissertation, I examine union organizing in the Canadian banking industry between 1940 and 1980. By demonstrating that bank workers consistently sought to unionize throughout the twentieth century, I challenge claims that bank employees and other private sector white-collar workers have low rates of unionization because they are not interested in unions or suffer from false consciousness. This research also suggests, however, that many bank workers saw themselves as different from blue-collar industrial workers; the lived reality of bank work as precarious, poorly paid, and rife with gender inequality intersected with ideas about professionalism and aspirations of advancing up the career ladder. Banks, unions, and workers drew on these ideas and experiences in their arguments for and against unionization.

I also look at why previous organizing efforts did not establish a strong union presence in the banking industry. Most of these attempts failed, I argue, due to several key issues, including the banks' anti-union activity, federal and provincial labour board decisions, and labour movement disputes over ideology, jurisdiction, and strategy. The banks consistently opposed unionization and used a variety of tactics to thwart union organizing, both overtly and covertly. The state, in the form of labour legislation and labour boards, provided unions and workers with some means by which to compel the banks to recognize unions, negotiate contracts, and deal with employee grievances; however, state action and inaction more often worked to undermine union organizing. The attitudes and strategies of high-ranking labour movement officials also shaped the outcome of union drives in the banks. Between 1940 and 1980, the mostly male labour leadership repeatedly used top-down organizing strategies and appointed male organizers with no experience of bank work to oversee union drives in a sector with an increasingly feminized workforce; labour leaders' inability or unwillingness to reflect on this approach and to support grassroots campaigns and alternative strategies hindered bank union organizing. I thus highlight the intersection of gender and class and reveal how these factors have historically shaped the labour movement bureaucracy, union organizing, and the relationship between labour and the state.

Author Keywords: banks, gender, labour bureaucracy, trade unions, union organizing, white-collar workers

Past research has examined the influence of cultural scripts on our first coital experience, but the impact of virginity scripts on precoital sexual behaviour remains unknown. The purpose of this study sought to examine the link between Carpenter's (2001) cognitive frameworks of virginity and precoital sexual behaviour. Two hundred and forty eight participants (32 men, 215 women, and one unknown) were recruited from a Canadian university, all of whom had experienced precoital behaviour and first sexual intercourse. The findings indicated that past precoital behaviour and coital behaviour with first sexual partner had different relationship patterns with respect to virginity scripts. Virginity scripts were also related to current sexual sensation seeking, motivation for erotic arousal, sexual compatibility, comfort with sexuality, and approach to sexual relationships.

Author Keywords: precoital sexual behaviour, sexual scripts, virginity frameworks, virginity loss